The Na+/K+-ATPase: A potential therapeutic target in cardiometabolic diseases

Milan Obradovic; Emina Sudar-Milovanovic; Zoran Gluvic; Katarina Banjac; Manfredi Rizzo; Esma R Isenovic

doi:10.3389/fendo.2023.1150171

The Na⁺/K⁺-ATPase: A potential therapeutic target in cardiometabolic diseases

Front Endocrinol (Lausanne). 2023 Feb 28:14:1150171. doi: 10.3389/fendo.2023.1150171. eCollection 2023.

Authors

Milan Obradovic¹, Emina Sudar-Milovanovic¹, Zoran Gluvic², Katarina Banjac¹, Manfredi Rizzo³, Esma R Isenovic¹

Affiliations

¹ Department of Radiobiology and Molecular Genetics, "VINČA" Institute of Nuclear Sciences - National Institute of thе Republic of Serbia, University of Belgrade, Belgrade, Serbia.
² University Clinical-Hospital Centre Zemun-Belgrade, Clinic of Internal medicine, School of Medicine, University of Belgrade, Belgrade, Serbia.
³ School of Medicine, Promise Department, University of Palermo, Palermo, Italy.

Abstract

Cardiometabolic diseases (CMD) are a direct consequence of modern living and contribute to the development of multisystem diseases such as cardiovascular diseases and diabetes mellitus (DM). CMD has reached epidemic proportions worldwide. A sodium pump (Na⁺/K⁺-ATPase) is found in most eukaryotic cells' membrane and controls many essential cellular functions directly or indirectly. This ion transporter and its isoforms are important in the pathogenesis of some pathological processes, including CMD. The structure and function of Na⁺/K⁺-ATPase, its expression and distribution in tissues, and its interactions with known ligands such as cardiotonic steroids and other suspected endogenous regulators are discussed in this review. In addition, we reviewed recent literature data related to the involvement of Na⁺/K⁺-ATPase activity dysfunction in CMD, focusing on the Na⁺/K⁺-ATPase as a potential therapeutic target in CMD.

Keywords: Na+/K+-ATPase; cardiometabolic diseases; cardiovascular diseases; therapy; type 2 diabetes mellitus.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cardiac Glycosides* / chemistry
Cardiac Glycosides* / metabolism
Cardiovascular Diseases* / drug therapy
Cell Membrane / metabolism
Humans
Sodium-Potassium-Exchanging ATPase

Substances

Cardiac Glycosides
Sodium-Potassium-Exchanging ATPase

Grants and funding

This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Contract No# 451-03-47/2023-01/200017).