Non-stoichiometric carbamazepine cocrystal hydrates of 3,4-/3,5-dihydroxybenzoic acids: coformer-water exchange

Trishna Rajbongshi; Kashyap Kumar Sarmah; Susobhan Das; Poonam Deka; Arijit Saha; Binoy K Saha; Horst Puschmann; C Malla Reddy; Ranjit Thakuria

doi:10.1039/d2cc06860e

Non-stoichiometric carbamazepine cocrystal hydrates of 3,4-/3,5-dihydroxybenzoic acids: coformer-water exchange

Chem Commun (Camb). 2023 Mar 28;59(26):3902-3905. doi: 10.1039/d2cc06860e.

Authors

Trishna Rajbongshi¹, Kashyap Kumar Sarmah², Susobhan Das³, Poonam Deka¹, Arijit Saha^{3

4}, Binoy K Saha⁴, Horst Puschmann⁵, C Malla Reddy³, Ranjit Thakuria¹

Affiliations

¹ Department of Chemistry, Gauhati University, Guwahati, 781014, India. ranjit.thakuria@gmail.com.
² Department of Chemistry, Behali Degree College, Borgang, Biswanath, 784167, Assam, India.
³ Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur, 741246, India. cmallareddy@gmail.com.
⁴ Department of Chemistry, Pondicherry University, Pondicherry, India.
⁵ OlexSys Ltd, Durham University, South Road, Durham, DH1 3LE, UK.

PMID: 36919569
DOI: 10.1039/d2cc06860e

Abstract

The cocrystallisation of carbamazepine (CBZ) with 3,4-/3,5-dihydroxybenzoic acids (34/35DHBA) with different stoichiometries formed molecular alloys, exchanging a water molecule, in their isostructural CBZ dihydrate form. Furthermore, we show a correlation between the mechanical properties of the CBZ-DHBA cocrystals with the amount of coformer present.