Behavioral characteristics in sensing mechanism of the Corti

Junyi Liang; Jiakun Wang; Wenjuan Yao; Lei Zhou; Xinsheng Huang

doi:10.1016/j.csbj.2023.02.030

Behavioral characteristics in sensing mechanism of the Corti

Comput Struct Biotechnol J. 2023 Feb 18:21:1797-1806. doi: 10.1016/j.csbj.2023.02.030. eCollection 2023.

Authors

Junyi Liang¹, Jiakun Wang², Wenjuan Yao², Lei Zhou³, Xinsheng Huang³

Affiliations

¹ Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44106, USA.
² Shanghai Institute of Applied Mathematics and Mechanics, Shanghai 200072, PR China.
³ Department of Otorhinolaryngology, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.

Abstract

Some experiments can't be realized because the cochlea's Corti is the most delicate and complex sensory organ. In this paper, some typical and special behavioral characteristics in the process of sensation were found in medical clinic. Based on the interdisciplinary principles of medicine, physics and biology, a real numerical simulation model of Corti is established. On the basis of verifying the correctness of the model, the mechanism corresponding to these typical and special behavior characteristics in the process of sensation is explored through simulation calculation and analysis. This study provides theoretical and applied basis for people to better understand the sound sensing mechanism, and provides a numerical simulation platform for further analyzing Corti's sensing mechanism and good clinical application.

Keywords: Corti; Interdisciplinary; Numerical simulation; Sound sensing mechanism; Typical behavioral characteristics.