DDX47 untangles R-loops with only certain other helicases

Zhenbao Yu; Stéphane Richard

doi:10.1016/j.tcb.2023.03.001

DDX47 untangles R-loops with only certain other helicases

Trends Cell Biol. 2023 May;33(5):359-360. doi: 10.1016/j.tcb.2023.03.001. Epub 2023 Mar 11.

Authors

Zhenbao Yu¹, Stéphane Richard²

Affiliations

¹ Segal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, Québec H3T 1E2, Canada; Gerald Bronfman Department of Oncology McGill University, Montréal, Québec H3T 1E2, Canada; Department of Biochemistry, McGill University, Montréal, Québec H3T 1E2, Canada; Department of Human Genetics McGill University, Montréal, Québec H3T 1E2, Canada; Department of Medicine, McGill University, Montréal, Québec H3T 1E2, Canada.
² Segal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, Québec H3T 1E2, Canada; Gerald Bronfman Department of Oncology McGill University, Montréal, Québec H3T 1E2, Canada; Department of Biochemistry, McGill University, Montréal, Québec H3T 1E2, Canada; Department of Human Genetics McGill University, Montréal, Québec H3T 1E2, Canada; Department of Medicine, McGill University, Montréal, Québec H3T 1E2, Canada. Electronic address: stephane.richard@mcgill.ca.

PMID: 36914533
DOI: 10.1016/j.tcb.2023.03.001

Abstract

R-loops, formed transiently during gene transcription, are tightly controlled to avoid conflict with ongoing processes. Marchena-Cruz et al. identified DExD/H box RNA helicase DDX47 using a new R-loop resolving screen and defined a unique role for this helicase in nucleolar R-loops and its interplay with senataxin (SETX) and DDX39B.

Keywords: DDX47; R-loop; RNA helicase; nucleolus.

MeSH terms

DEAD-box RNA Helicases* / genetics
DEAD-box RNA Helicases* / metabolism
DNA Helicases
Humans
Multifunctional Enzymes / genetics
R-Loop Structures*
RNA Helicases / genetics

Substances

DEAD-box RNA Helicases
SETX protein, human
DNA Helicases
RNA Helicases
Multifunctional Enzymes