Impact of baseline right ventricular function on the response to cardiac resynchronization therapy - A meta-analysis

Georgios Sidiropoulos; Antonios Antoniadis; Athanasios Saplaouras; Georgios Bazoukis; Κonstantinos P Letsas; Theodoros D Karamitsos; Georgios Giannopoulos; Nikolaos Fragakis

doi:10.1016/j.hjc.2023.03.002

Impact of baseline right ventricular function on the response to cardiac resynchronization therapy - A meta-analysis

Hellenic J Cardiol. 2023 Sep-Oct:73:61-68. doi: 10.1016/j.hjc.2023.03.002. Epub 2023 Mar 11.

Authors

Georgios Sidiropoulos¹, Antonios Antoniadis², Athanasios Saplaouras³, Georgios Bazoukis⁴, Κonstantinos P Letsas⁵, Theodoros D Karamitsos⁶, Georgios Giannopoulos⁷, Nikolaos Fragakis⁸

Affiliations

¹ Department of Cardiology, Georgios Papanikolaou General Hospital, Leoforos Papanikolaou, Pylaia, Thessaloniki, PK 57010, Greece. Electronic address: sidiropoulos.georges@gmail.com.
² 3(rd) Cardiology Department, Hippokration General Hospital, Aristotle University Medical School, Κonstantinoupoleos 49, Thessaloniki, PK 54642, Greece. Electronic address: aantoniadis@gmail.com.
³ Onassis Cardiac Surgery Center, Electrophysiology Department, Leoforos Andrea Syggrou 356, Athens, PK 17674, Greece. Electronic address: saplaouras@hotmail.com.
⁴ Department of Cardiology Larnaca General Hospital, Pandoras Street, Larnaca, PK 6301, Cyprus; Department of Basic and Clinical Sciences, University of Nicosia Medical School, 93 Agiou Nikolaou Street, Engomi, Nicosia, Cyprus. Electronic address: gbazoykis@yahoo.gr.
⁵ Onassis Cardiac Surgery Center, Electrophysiology Department, Leoforos Andrea Syggrou 356, PK 17674, Athens, Greece. Electronic address: letsaskpa@yahoo.co.uk.
⁶ 1(st) Cardiology Department, AHEPA University Hospital, Aristotle University Medical School, Kiriakidi 1, Thessaloniki, PK 54636, Greece. Electronic address: tkaramitsos@auth.gr.
⁷ 3(rd) Cardiology Department, Hippokration General Hospital, Aristotle University Medical School, Κonstantinoupoleos 49, Thessaloniki, PK 54642, Greece. Electronic address: ggiann@auth.gr.
⁸ 2(nd) Cardiology Department, Hippokration General Hospital, Aristotle University Medical School, Κonstantinoupoleos 49, Thessaloniki, PK 54642, Greece. Electronic address: fragakis.nikos@googlemail.com.

PMID: 36914097
DOI: 10.1016/j.hjc.2023.03.002

Abstract

Baseline right ventricular (RV) function potentially determines the response to Cardiac Resynchronization Therapy (CRT) but is not included in the current selection criteria. In this meta-analysis, we examined the value of echocardiographic indices of RV function as potential predictors of CRT outcomes in patients with standard indications for CRT. Baseline tricuspid annular plane systolic excursion was consistently higher in CRT responders, and this association appears independent of age, sex, ischemic etiology of heart failure, and baseline left ventricular ejection fraction. This proof-of-concept meta-analysis of observational data may justify a more detailed assessment of RV function as an additional component in the selection process of CRT candidates.

Keywords: Cardiac resynchronization therapy response; Right ventricular fractional area change; Right ventricular function; Right ventricular global longitudinal strain; Tricuspid annular plane systolic excursion.

Publication types

Meta-Analysis
Review

MeSH terms

Cardiac Resynchronization Therapy*
Heart Failure*
Humans
Stroke Volume
Treatment Outcome
Ventricular Dysfunction, Right* / therapy
Ventricular Function, Left
Ventricular Function, Right / physiology