The relationship between FGF23 and body composition according to albuminuria stage in type 1 diabetes

Erika B Parente; Aila J Ahola; Anmol Kumar; Markku Lehto; Per-Henrik Groop; FinnDiane Study Group

doi:10.1016/j.diabres.2023.110620

The relationship between FGF23 and body composition according to albuminuria stage in type 1 diabetes

Diabetes Res Clin Pract. 2023 Apr:198:110620. doi: 10.1016/j.diabres.2023.110620. Epub 2023 Mar 12.

Authors

Erika B Parente¹, Aila J Ahola¹, Anmol Kumar¹, Markku Lehto¹, Per-Henrik Groop²; FinnDiane Study Group

Affiliations

¹ Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland; Department of Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Finland.
² Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland; Department of Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Finland; Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia. Electronic address: per-henrik.groop@helsinki.fi.

PMID: 36914006
DOI: 10.1016/j.diabres.2023.110620

Abstract

Aims: Fibroblast growth factor 23 (FGF23) and obesity are linked to kidney disease. However, the relationship between FGF23 and body composition is unclear. Associations between FGF23 and body composition were investigated in type 1 diabetes from the Finnish Diabetic Nephropathy Study according to albuminuria stages.

Methods: Data were available from 306 adults with type 1 diabetes (229 normal albumin excretion rate, T1D^normo; 38 microalbuminuria, T1D^micro; 39 macroalbuminuria, T1D^macro), and 36 controls. Serum FGF23 was measured by ELISA. Body composition was assessed with dual-energy X-ray absorptiometry. Associations between body composition and serum FGF23 were investigated using linear regression models.

Results: Compared with T1D^normo, individuals with more advanced kidney disease were older, had longer diabetes duration, higher serum hsCRP, and higher FGF23 concentration. However, FGF23 concentration was comparable between T1D^normo and controls. Adjusted for potential confounders, in T1D^micro, FGF23 was positively associated with the percentages of total fat, visceral fat, and android fat tissues, while negative associations between FGF23 and lean tissue were observed. FGF23 was not associated with body composition in T1D^normo, T1D^macro, and controls.

Conclusions: In type 1 diabetes, the relationship between FGF23 and body composition is dependent on albuminuria stages.

Keywords: Body composition; Diabetic kidney disease; FGF23; Type 1 diabetes; Visceral fat.

MeSH terms

Adult
Albuminuria
Body Composition
Diabetes Mellitus, Type 1*
Diabetic Nephropathies*
Humans
Obesity

Substances

FGF23 protein, human