ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis

Cancer Res. 2023 Jun 2;83(11):1851-1865. doi: 10.1158/0008-5472.CAN-22-3490.

Abstract

Metastatic cancer cells upregulate ANO1 to activate cell-intrinsic and -extrinsic mechanisms that alter cholesterol metabolism and stimulate fibroblasts, which can be targeted with ANO1 inhibitors to inhibit metastatic growth. See related commentary by Singh and Mehla, p. 1759.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anoctamin-1 / metabolism
  • Cell Line, Tumor
  • Cholesterol / metabolism
  • Fibroblasts / metabolism
  • Humans
  • Neoplasm Proteins* / metabolism
  • Neoplasms* / metabolism
  • Tumor Microenvironment

Substances

  • Neoplasm Proteins
  • Cholesterol
  • Anoctamin-1
  • ANO1 protein, human