Heinz body hemolysis following extended use phenazopyridine in a post-HCT patient with hemorrhagic cystitis: An old problem for a new generation

Asmaa Ferdjallah; Susie Long; Vanessa Dayton; Ashish O Gupta

doi:10.1002/ccr3.7012

Heinz body hemolysis following extended use phenazopyridine in a post-HCT patient with hemorrhagic cystitis: An old problem for a new generation

Clin Case Rep. 2023 Mar 7;11(3):e7012. doi: 10.1002/ccr3.7012. eCollection 2023 Mar.

Authors

Asmaa Ferdjallah¹, Susie Long², Vanessa Dayton³, Ashish O Gupta¹

Affiliations

¹ Division of Blood and Marrow Transplant and Cellular Therapy, Department of Pediatrics University of Minnesota Minneapolis Minnesota USA.
² MHealth Fairview, Acute Care Pharmacy Services Minneapolis Minnesota USA.
³ Department of Pathology, Hematopathology University of Minnesota Minneapolis Minnesota USA.

Abstract

Hemorrhagic cystitis is a common complication following the use of cyclophosphamide. Associated dysuria can be painful and there are few good options to relieve pain. Phenazopyridine has historically been utilized for dysuria and is available over the counter. However, it is associated with hematologic side effects with prolonged use. Here we present a case of a patient who developed Heinz body hemolysis following prolonged administration of phenazopyridine to treat cyclophosphamide-induced hemorrhagic cystitis following hematopoietic stem cell transplant.

Keywords: Heinz body; hemolysis; hemorrhagic cystitis; pediatrics; phenazopyridine.

Publication types

Case Reports