Mitophagy in ototoxicity

Hezhou Han; Sainan Hu; Yue Hu; Dongliang Liu; Junbo Zhou; Xiaofang Liu; Xiulan Ma; Yaodong Dong

doi:10.3389/fncel.2023.1140916

Mitophagy in ototoxicity

Front Cell Neurosci. 2023 Feb 23:17:1140916. doi: 10.3389/fncel.2023.1140916. eCollection 2023.

Authors

Hezhou Han¹, Sainan Hu¹, Yue Hu¹, Dongliang Liu¹, Junbo Zhou², Xiaofang Liu³, Xiulan Ma¹, Yaodong Dong¹

Affiliations

¹ Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang, China.
² Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
³ Department of Surgical Oncology, The First Affiliated Hospital of China Medical University, Shenyang, China.

Abstract

Mitochondrial dysfunction is associated with ototoxicity, which is caused by external factors. Mitophagy plays a key role in maintaining mitochondrial homeostasis and function and is regulated by a series of key mitophagy regulatory proteins and signaling pathways. The results of ototoxicity models indicate the importance of this process in the etiology of ototoxicity. A number of recent investigations of the control of cell fate by mitophagy have enhanced our understanding of the mechanisms by which mitophagy regulates ototoxicity and other hearing-related diseases, providing opportunities for targeting mitochondria to treat ototoxicity.

Keywords: PINK1-Parkin; autophagy receptors; mitochondria; mitophagy; ototoxicity.

Publication types

Review

Grants and funding

This work was supported by grants obtained from the National Natural Science Foundation of China (Grant No. 92168115, YD), the Science Foundation for Outstanding Young Scholars of Liaoning Province (Grant No. 2022-YQ-16, YD), the National Key R&D Program “Active Health and Aging Technology Response” (Grant No. 2020YFC2005200, XM), the Liaoning Provincial Natural Science Foundation (grant no. 2020-MS-157, XL), 345 Talent Project of Shengjing Hospital (Grant No. M1400, YD), the Project of City-University Cooperation (Grant no. 2400022047, YD), and the Natural Science Foundation of Liaoning Province (Grant no. 2022-RS-124, YH).