Senescent cell: the 'factory of viral amplification'

Qiang Chen; Wei Mo

doi:10.1016/j.tim.2023.02.012

Senescent cell: the 'factory of viral amplification'

Trends Microbiol. 2023 May;31(5):421-422. doi: 10.1016/j.tim.2023.02.012. Epub 2023 Mar 10.

Authors

Qiang Chen¹, Wei Mo²

Affiliations

¹ State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China. Electronic address: chenqiang1@stu.xmu.edu.cn.
² State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China. Electronic address: wmo@xmu.edu.cn.

PMID: 36907744
DOI: 10.1016/j.tim.2023.02.012

Abstract

It has been demonstrated that reactivation of endogenous retroviruses (ERVs), the remnants of ancient retroviral infection, participate in various physiological and pathological conditions. Liu et al. recently showed us very interesting findings that aberrant expression of ERVs, induced by epigenetic alterations, accelerates cellular senescence.

MeSH terms

Cellular Senescence*
Endogenous Retroviruses* / genetics
Epigenesis, Genetic*