Antiproliferative activity of compounds isolated from the root bark of Lannea acida in multiple myeloma cell lines

Noémie Saraux; Laure Bruna; Samad N Ebrahimi; Soumana Karimou; Philippe Christen; Muriel Cuendet

doi:10.1016/j.phytochem.2023.113641

Antiproliferative activity of compounds isolated from the root bark of Lannea acida in multiple myeloma cell lines

Phytochemistry. 2023 May:209:113641. doi: 10.1016/j.phytochem.2023.113641. Epub 2023 Mar 10.

Authors

Noémie Saraux¹, Laure Bruna², Samad N Ebrahimi³, Soumana Karimou⁴, Philippe Christen⁵, Muriel Cuendet⁶

Affiliations

¹ School of Pharmaceutical Sciences, University of Geneva, Rue Michel-Servet 1, 1211, Geneva 4, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Rue Michel-Servet 1, 1211, Geneva 4, Switzerland. Electronic address: noemie.saraux@unige.ch.
² School of Pharmaceutical Sciences, University of Geneva, Rue Michel-Servet 1, 1211, Geneva 4, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Rue Michel-Servet 1, 1211, Geneva 4, Switzerland. Electronic address: laurebruna@gmail.com.
³ Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, 1983963113, Tehran, Iran. Electronic address: s_ebrahimi@sbu.ac.ir.
⁴ Plantasav, B.P. 10308, Niamey, Niger. Electronic address: kdekossa@yahoo.fr.
⁵ School of Pharmaceutical Sciences, University of Geneva, Rue Michel-Servet 1, 1211, Geneva 4, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Rue Michel-Servet 1, 1211, Geneva 4, Switzerland. Electronic address: philippe.christen@unige.ch.
⁶ School of Pharmaceutical Sciences, University of Geneva, Rue Michel-Servet 1, 1211, Geneva 4, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Rue Michel-Servet 1, 1211, Geneva 4, Switzerland. Electronic address: muriel.cuendet@unige.ch.

PMID: 36907430
DOI: 10.1016/j.phytochem.2023.113641

Abstract

Lannea acida A. Rich. is a native plant of West Africa used in traditional medicine against diarrhea, dysentery, rheumatism, and women infertility. Eleven compounds were isolated from the dichloromethane root bark extract using various chromatographic techniques. Among those, nine compounds have not been previously reported, i.e. one cardanol derivative, two alkenyl 5-hydroxycyclohex-2-en-1-ones, three alkenyl cyclohex-4-ene-1,3-diols, two alkenyl 7-oxabicyclo[4.1.0]hept-4-en-3-ols, and one alkenyl 4,5-dihydroxycyclohex-2-en-1-one, together with two known cardanols. The structure of the compounds was elucidated using NMR, HRESIMS, ECD, IR, and UV. Their antiproliferative activity was evaluated in three multiple myeloma cell lines: RPMI 8226, MM.1S, and MM.1R. Two compounds showed activity in all cell lines with IC₅₀ values < 5 μM. Further investigations are needed to understand the mechanism of action.

Keywords: Anacardiaceae; Antiproliferative activity; Bioassay-guided fractionation; Cardanols; Cyclohexenol; Cyclohexenone; Lannea acida; Multiple myeloma.

MeSH terms

Anacardiaceae* / chemistry
Cell Line, Tumor
Multiple Myeloma* / drug therapy
Plant Bark / chemistry
Plant Extracts / chemistry

Substances

Plant Extracts