Insulin Therapy in Small Animals, Part 2: Cats

Linda Fleeman; Chen Gilor

doi:10.1016/j.cvsm.2023.02.004

Insulin Therapy in Small Animals, Part 2: Cats

Vet Clin North Am Small Anim Pract. 2023 May;53(3):635-644. doi: 10.1016/j.cvsm.2023.02.004. Epub 2023 Mar 9.

Authors

Linda Fleeman¹, Chen Gilor²

Affiliations

¹ Animal Diabetes Australia, 5 Hood Street, Collingwood, Victoria 3066, Australia. Electronic address: L.Fleeman@AnimalDiabetesAustralia.com.au.
² Small Animal Internal Medicine, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 Southwest 16th Avenue, Gainesville, FL 32608, USA.

PMID: 36906468
DOI: 10.1016/j.cvsm.2023.02.004

Abstract

No insulin formulation should be considered best by default for management of feline diabetes. Rather, the choice of insulin formulation should be tailored to the specific clinical situation. In most cats that have some residual beta cell function, administering only a basal insulin might lead to complete normalization of blood glucose concentrations. Basal insulin requirements are constant throughout the day. Therefore, for an insulin formulation to be effective and safe as a basal insulin, its action should be roughly the same every hour of the day. At present, only insulin glargine U300 approaches this definition in cats.

Keywords: Basal insulin; Diabetes mellitus; Feline; Glargine U300.

Publication types

Review

MeSH terms

Animals
Blood Glucose
Cat Diseases* / drug therapy
Cats
Diabetes Mellitus* / drug therapy
Diabetes Mellitus* / veterinary
Diabetes Mellitus, Type 2* / drug therapy
Diabetes Mellitus, Type 2* / veterinary
Hypoglycemic Agents / therapeutic use
Insulin / therapeutic use
Insulin Glargine / therapeutic use

Substances

Insulin
Hypoglycemic Agents
Insulin Glargine
Blood Glucose