IgD-CD27- double negative (DN) B cells: Origins and functions in health and disease

Lien Beckers; Veerle Somers; Judith Fraussen

doi:10.1016/j.imlet.2023.03.003

IgD^-CD27^- double negative (DN) B cells: Origins and functions in health and disease

Immunol Lett. 2023 Mar:255:67-76. doi: 10.1016/j.imlet.2023.03.003. Epub 2023 Mar 9.

Authors

Lien Beckers¹, Veerle Somers¹, Judith Fraussen²

Affiliations

¹ University MS Center (UMSC), Hasselt-Pelt, Hasselt, Belgium; Department of Immunology and Infection, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
² University MS Center (UMSC), Hasselt-Pelt, Hasselt, Belgium; Department of Immunology and Infection, Biomedical Research Institute, Hasselt University, Hasselt, Belgium. Electronic address: judith.fraussen@uhasselt.be.

PMID: 36906182
DOI: 10.1016/j.imlet.2023.03.003

Abstract

Human B cells can be divided into four main subsets based on differential expression of immunoglobulin (Ig)D and CD27. IgD^-CD27^- double negative (DN) B cells make up a heterogeneous group of B cells that have first been described in relation to aging and systemic lupus erythematosus but have been mostly disregarded in B cell research. Over the last few years, DN B cells have gained a lot of interest because of their involvement in autoimmune and infectious diseases. DN B cells can be divided into different subsets that originate via different developmental processes and have different functional properties. Further research into the origin and function of different DN subsets is needed to better understand the role of these B cells in normal immune responses and how they could be targeted in specific pathologies. In this review, we give an overview of both phenotypic and functional properties of DN B cells and provide insight into the currently proposed origins of DN B cells. Moreover, their involvement in normal aging and different pathologies is discussed.

Keywords: Aging; Autoimmune disease; B cells; Double negative; IgD(−)CD27(−).

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aging
B-Lymphocyte Subsets*
B-Lymphocytes
Humans
Immunoglobulin D / metabolism
Immunologic Memory
Lupus Erythematosus, Systemic*
Tumor Necrosis Factor Receptor Superfamily, Member 7 / metabolism

Substances

Immunoglobulin D
Tumor Necrosis Factor Receptor Superfamily, Member 7