Hipposponols A and B, two new 9, 11-secosterols from the marine sponge Hippospongia lachne de Laubenfels

Ya-Fang Ding; Li-Yun Liu; Jie Tang; Dong-Xue Fan; Yuan-Yuan Ji; Hou-Wen Lin; Jie Wang; Li-Li Hong

doi:10.1080/14786419.2023.2188588

Hipposponols A and B, two new 9, 11-secosterols from the marine sponge Hippospongia lachne de Laubenfels

Nat Prod Res. 2023 Mar 10:1-7. doi: 10.1080/14786419.2023.2188588. Online ahead of print.

Authors

Ya-Fang Ding^{1

2}, Li-Yun Liu², Jie Tang², Dong-Xue Fan^{2

3}, Yuan-Yuan Ji^{2

4}, Hou-Wen Lin², Jie Wang¹, Li-Li Hong²

Affiliations

¹ School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, China.
² Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
³ School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China.
⁴ College of Food Science and Technology, Shanghai Ocean University, Shanghai, China.

PMID: 36905167
DOI: 10.1080/14786419.2023.2188588

Abstract

Two new 9,11-secosterols, hipposponols A (1) and B (2), together with five known analogues, aplidiasterol B (3), (3β,5α,6β)-3,5,6-triol-cholest-7-ene (4), (3β,5α,6β,22E)-3,5,6-triol-ergosta-7,22-diene (5), and one pair of inseparable C-24 epimers of (3β,5α,6β,22E)-3,5,6-triol-stigmasta-7,22-diene (6/7), were isolated from the marine sponge Hippospongia lachne de Laubenfels. The structures of isolated compounds were extensively elucidated based on HRESIMS and NMR data. Compounds 2 - 5 showed cytotoxicity against PC9 cells with IC₅₀ values ranging from 34.1 ± 0.9 to 38.9 ± 1.0 µM and compound 4 displayed cytotoxicity against MCF-7 cells with IC₅₀ value of 39.0 ± 0.4 µM.

Keywords: Hippospongia lachne de Laubenfels; Marine sponge; cytotoxicity; secosterol.