Electro-Oxidative C3-Selenylation of Pyrido[1,2- a]pyrimidin-4-ones

Jianwei Shi; Zhichuan Wang; Xiaoxu Teng; Bing Zhang; Kai Sun; Xin Wang

doi:10.3390/molecules28052206

Electro-Oxidative C3-Selenylation of Pyrido[1,2- a]pyrimidin-4-ones

Molecules. 2023 Feb 27;28(5):2206. doi: 10.3390/molecules28052206.

Authors

Jianwei Shi¹, Zhichuan Wang², Xiaoxu Teng¹, Bing Zhang³, Kai Sun², Xin Wang²

Affiliations

¹ School of Chemistry and Chemical Engineering, Yangtze Normal University, Chongqing 408100, China.
² College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China.
³ College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.

Abstract

In this work, we achieved a C3-selenylation of pyrido[1,2-a]pyrimidin-4-ones using an electrochemically driven external oxidant-free strategy. Various structurally diverse seleno-substituted N-heterocycles were obtained in moderate to excellent yields. Through radical trapping experiments, GC-MS analysis and cyclic voltammetry study, a plausible mechanism for this selenylation was proposed.

Keywords: N-heterocycles; carbocation; electrochemistry; radical; selenylation.

Abstract

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