The effects of N6-methyladenosine RNA methylation on the nervous system

Nan Shao; Ting Ye; Weiting Xuan; Meng Zhang; Qian Chen; Juan Liu; Peng Zhou; Hang Song; Biao Cai

doi:10.1007/s11010-023-04691-6

The effects of N⁶-methyladenosine RNA methylation on the nervous system

Mol Cell Biochem. 2023 Dec;478(12):2657-2669. doi: 10.1007/s11010-023-04691-6. Epub 2023 Mar 10.

Authors

Nan Shao^#¹, Ting Ye^#¹, Weiting Xuan², Meng Zhang¹, Qian Chen¹, Juan Liu³, Peng Zhou^{4

5

6

7}, Hang Song^{8

9

10

11}, Biao Cai^{12

13

14

15}

Affiliations

¹ College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China.
² Department of Neurosurgery (Rehabilitation), Anhui Hospital of Integrated Chinese and Western Medicine, Hefei, 230031, China.
³ Department of Chinese Internal Medicine, Taihe County People's Hospital, Fuyang, 236699, China.
⁴ College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China. zhoupeng@ahtcm.edu.cn.
⁵ Institute of Integrated Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei, 230012, China. zhoupeng@ahtcm.edu.cn.
⁶ Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, 230012, China. zhoupeng@ahtcm.edu.cn.
⁷ Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, 230012, China. zhoupeng@ahtcm.edu.cn.
⁸ College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China. hangsong@ahtcm.edu.cn.
⁹ Institute of Integrated Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei, 230012, China. hangsong@ahtcm.edu.cn.
¹⁰ Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, 230012, China. hangsong@ahtcm.edu.cn.
¹¹ Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, 230012, China. hangsong@ahtcm.edu.cn.
¹² College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China. caibiao@ahtcm.edu.cn.
¹³ Institute of Integrated Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei, 230012, China. caibiao@ahtcm.edu.cn.
¹⁴ Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, 230012, China. caibiao@ahtcm.edu.cn.
¹⁵ Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, 230012, China. caibiao@ahtcm.edu.cn.

^# Contributed equally.

PMID: 36899139
DOI: 10.1007/s11010-023-04691-6

Abstract

Epitranscriptomics, also known as "RNA epigenetics", is a type of chemical modification that regulates RNA. RNA methylation is a significant discovery after DNA and histone methylation. The dynamic reversible process of m⁶A involves methyltransferases (writers), m⁶A binding proteins (readers), as well as demethylases (erasers). We summarized the current research status of m⁶A RNA methylation in the neural stem cells' growth, synaptic and axonal function, brain development, learning and memory, neurodegenerative diseases, and glioblastoma. This review aims to provide a theoretical basis for studying the mechanism of m⁶A methylation and finding its potential therapeutic targets in nervous system diseases.

Keywords: Modification enzyme; Nervous system; RNA epigenetics; m6A methylation.

Publication types

Review

MeSH terms

Methylation
Methyltransferases* / metabolism
Nervous System / metabolism
RNA* / metabolism

Substances

N-methyladenosine
RNA
Methyltransferases

Abstract

Publication types

MeSH terms

Substances

Grants and funding