Clinical practice - latest insights in optimizing the care of children with Down syndrome

Eur J Pediatr. 2023 May;182(5):2027-2039. doi: 10.1007/s00431-023-04890-9. Epub 2023 Mar 10.

Abstract

An essential part of the care of children with Down syndrome is secondary screening for comorbidity. It is well known that comorbidity frequently occurs in these children. A new update of the Dutch Down syndrome medical guideline was developed to create a sound evidence base for several of these conditions. We present the latest insights and recommendations from this Dutch medical guideline which are based on the most relevant literature currently available and developed with rigorous methodology. The main focus of this revision of the guideline was on obstructive sleep apnea and other airway problems and hematologic disorders, such as transient abnormal myelopoiesis, leukemia, and thyroid disorders. Conclusion: This is a short summary of the latest insights and recommendations from the updated Dutch medical guideline for children with Down syndrome.

Keywords: Care; Children; Congenital abnormalities; Down syndrome; Guideline; Trisomy 21.

Publication types

  • Review

MeSH terms

  • Child
  • Comorbidity
  • Down Syndrome* / complications
  • Down Syndrome* / diagnosis
  • Down Syndrome* / therapy
  • Humans
  • Sleep Apnea, Obstructive* / diagnosis
  • Sleep Apnea, Obstructive* / epidemiology
  • Sleep Apnea, Obstructive* / therapy