CRISPR-based screening identifies XPO7 as a positive regulator of senescence

Lan-Zhu Li; Kuan Yang; Yaobin Jing; Yanling Fan; Xiaoyu Jiang; Si Wang; Guang-Hui Liu; Jing Qu; Shuai Ma; Weiqi Zhang

doi:10.1093/procel/pwad012

CRISPR-based screening identifies XPO7 as a positive regulator of senescence

Protein Cell. 2023 Aug 1;14(8):623-628. doi: 10.1093/procel/pwad012.

Authors

Lan-Zhu Li^{1

2

3

4}, Kuan Yang^{5

2

6}, Yaobin Jing^{1

2

3

4

7}, Yanling Fan^{5

2}, Xiaoyu Jiang^{1

2

3

4}, Si Wang^{8

9}, Guang-Hui Liu^{1

2

3

4

7

8

9}, Jing Qu^{10

2

3

4}, Shuai Ma^{1

2

3

4}, Weiqi Zhang^{5

2

3

7

6}

Affiliations

¹ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
² University of Chinese Academy of Sciences, Beijing 100049, China.
³ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
⁴ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.
⁵ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
⁶ Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China.
⁷ School of Future Technology, University of Chinese Academy of Sciences, Beijing 100190, China.
⁸ Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
⁹ Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
¹⁰ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

CRISPR-Cas Systems / genetics
Cell Nucleus*
Cellular Senescence* / genetics