Fecal microbiota transplantation as potential first-line treatment for patients with Clostridioides difficile infection and prior appendectomy

Jing-Wen Zhao; Bing Chang; Li-Xuan Sang

doi:10.4240/wjgs.v15.i2.303

Fecal microbiota transplantation as potential first-line treatment for patients with Clostridioides difficile infection and prior appendectomy

World J Gastrointest Surg. 2023 Feb 27;15(2):303-306. doi: 10.4240/wjgs.v15.i2.303.

Authors

Jing-Wen Zhao¹, Bing Chang², Li-Xuan Sang³

Affiliations

¹ Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang 110022, Liaoning Province, China.
² Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
³ Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang 110022, Liaoning Province, China. sanglixuan2008@163.com.

Abstract

Clostridioides difficile infection (CDI) is a global health problem. The association of appendectomy on the severity and prognosis of CDI has been reported in many literatures, but there are still contradictions. In a retrospective study entitled "Patients with Closterium diffuse infection and prior appendectomy may be prone to word outcomes" published in World J Gastrointest Surg 2021, the author found that prior appendectomy affects the severity of CDI. Appendectomy may be a risk factor for increasing the severity of CDI. Therefore, it is necessary to seek alternative treatment for patients with prior appendectomy when they are more likely to have severe or fulminant CDI.

Keywords: Appendectomy; Clostridioides difficile infection; Colectomy; Fecal microbiota transplantation; Intestinal microbiota; Toxic megacolon.