Relevant mechanisms of MAIT cells involved in the pathogenesis of periodontitis

Xinrong Jiang; Qingtong Zhao; Zhanyu Huang; Fengyu Ma; Kexiao Chen; Zejian Li

doi:10.3389/fcimb.2023.1104932

Relevant mechanisms of MAIT cells involved in the pathogenesis of periodontitis

Front Cell Infect Microbiol. 2023 Feb 21:13:1104932. doi: 10.3389/fcimb.2023.1104932. eCollection 2023.

Authors

Xinrong Jiang^{1

2}, Qingtong Zhao^{1

3}, Zhanyu Huang^{1

2}, Fengyu Ma^{1

2}, Kexiao Chen^{1

2}, Zejian Li^{1

4}

Affiliations

¹ Hospital of Stomatology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangzhou, Guangdong, China.
² College of Stomatology, Jinan University, Guangzhou, Guangdong, China.
³ Department of Stomatology, The Sixth Affiliated Hospital of Jinan University, Dongguan, Guangdong, China.
⁴ Chaoshan Hospital, The First Affiliated Hospital of Jinan University, Chaozhou, Guangdong, China.

Abstract

Mucosal-associated invariant T (MAIT) cells are a group of unconventional T cells that are abundant in the human body, recognize microbial-derived vitamin B metabolites presented by MHC class I-related protein 1 (MR1), and rapidly produce proinflammatory cytokines, which are widely involved in the immune response to various infectious diseases. In the oral mucosa, MAIT cells tend to accumulate near the mucosal basal lamina and are more inclined to secrete IL-17 when activated. Periodontitis is a group of diseases that manifests mainly as inflammation of the gums and resorption of the alveolar bone due to periodontal tissue invasion by plaque bacteria on the dental surface. The course of periodontitis is often accompanied by a T-cell-mediated immune response. This paper discussed the pathogenesis of periodontitis and the potential contribution of MAIT cells to periodontitis.

Keywords: IL-17; alveolar bone resorption; immune reaction; mucosal-associated invariant T cell; periodontitis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Communicable Diseases*
Cytokines / metabolism
Histocompatibility Antigens Class I
Humans
Mucosal-Associated Invariant T Cells* / metabolism
Periodontitis* / metabolism

Substances

Histocompatibility Antigens Class I
Cytokines

Grants and funding

This work was supported by Science and Technology Projects in Guangzhou (grant No. 202102020020, 202201020536, 202201020069) and Medical Joint Fund of Jinan University (Grant No. 34422037).