The SARS-CoV-2 Spike receptor binding domain and N-terminal domain interact with each other in an intricate mechanism. Mutations modulate the interplay between the Spike and host molecules. This editorial comments on the intricacies of SARS-CoV-2 Spike interactions.
Keywords: AXL; IntAct; N-terminal domain; SARS-CoV-2; Spike; allosteric interaction; electrostatic potential; indels; receptor binding domain; sialoside.
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