Combined CRAFITY score and α-fetoprotein response predicts treatment outcomes in patients with unresectable hepatocellular carcinoma receiving anti-programmed death-1 blockade-based immunotherapy

Wei-Fan Hsu; Hsueh-Chou Lai; Cheng-Kuo Chen; Hung-Wei Wang; Po-Heng Chuang; Ming-Hung Tsai; Sheng-Hung Chen; Chia-Sheng Chu; Wen-Pang Su; Jen-Wei Chou; Jung-Ta Kao; Hung-Yao Chen; Shih-Chieh Chuang; Tsung-Yu Tsai; Wang-De Hsiao; Guan-Tarn Huang; Cheng-Yuan Peng

Combined CRAFITY score and α-fetoprotein response predicts treatment outcomes in patients with unresectable hepatocellular carcinoma receiving anti-programmed death-1 blockade-based immunotherapy

Am J Cancer Res. 2023 Feb 15;13(2):654-668. eCollection 2023.

Authors

Wei-Fan Hsu^{1

2

3}, Hsueh-Chou Lai^{1

3}, Cheng-Kuo Chen⁴, Hung-Wei Wang^{1

5}, Po-Heng Chuang⁶, Ming-Hung Tsai⁷, Sheng-Hung Chen^{1

5}, Chia-Sheng Chu¹, Wen-Pang Su¹, Jen-Wei Chou¹, Jung-Ta Kao¹, Hung-Yao Chen¹, Shih-Chieh Chuang¹, Tsung-Yu Tsai¹, Wang-De Hsiao¹, Guan-Tarn Huang^{1

5}, Cheng-Yuan Peng^{1

5}

Affiliations

¹ Center for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital Taichung, Taiwan.
² Graduate Institute of Biomedical Science, China Medical University Taichung, Taiwan.
³ School of Chinese Medicine, China Medical University Taichung, Taiwan.
⁴ Division of Gastroenterology & Hepatology, Department of Internal Medicine, Asia University Hospital Taichung, Taiwan.
⁵ School of Medicine, China Medical University Taichung, Taiwan.
⁶ Division of Gastroenterology, Department of Internal Medicine, Jen-Ai General Hospital Taichung, Taiwan.
⁷ Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital Taichung, Taiwan.

PMID: 36895987
PMCID: PMC9989621

Abstract

Biomarkers for predicting the treatment efficacy of immune checkpoint inhibitor (ICI)-based therapy in patients with unresectable hepatocellular carcinoma (uHCC) are crucial. Previous studies demonstrated that C-reactive protein and alpha-fetoprotein (AFP) in immunotherapy (CRAFITY) score at baseline predicted treatment outcomes and that patients with uHCC with AFP response, defined as > 15% decline in AFP level within the initial 3 months of ICI-based therapy, had favorable outcomes when receiving ICI-based therapy. However, whether the combination of CRAFITY score and AFP response could be used to predict treatment efficacy of programmed death-1 (PD-1) blockade-based therapy in uHCC patients remains unclear. We retrospectively enrolled 110 consecutive uHCC patients from May 2017 to March 2022. The median ICI treatment duration was 2.85 (1.67-6.63) months, and 87 patients received combination therapies. The objective response and disease control rates were 21.8% and 46.4%, respectively. The duration of progression-free survival (PFS) and overall survival (OS) was 2.87 (2.16-3.58) months and 8.20 (4.23-12.17) months, respectively. We categorized patients into three groups based on CRAFITY score (2 vs 0/1) and AFP response: patients with a CRAFITY score of 0/1 and AFP response (Group 1), those with a CRAFITY score of 2 and no AFP response (group 3), and those who did not belong to Group 1 and 3 (i.e., Group 2). The combination of CRAFITY score and AFP response could predict disease control and could predict PFS compared with CRAFITY score or AFP response alone. The combination of CRAFITY score and AFP response was an independent predictor of OS (Group 2 vs Group 1, HR: 4.513, 95% CI 1.990-10.234; Group 3 vs Group 1, HR: 3.551, 95% CI 1.544-8.168). Our findings indicated that the combination of CRAFITY score and AFP response could predict disease control, PFS, and OS in uHCC patients receiving PD-1 blockade-based immunotherapy.

Keywords: AFP response; CRAFITY score; hepatocellular carcinoma; programmed death-1 blockade; survival.