Asymmetric ring-opening reactions of donor-acceptor cyclopropanes with 1,3-cyclodiones

Dongxin Zhang; Lvjia Chen; Huiqing Deng; Ying Zhang; Qihang Cheng; Qian-Feng Zhang

doi:10.1039/d2ra08257h

Asymmetric ring-opening reactions of donor-acceptor cyclopropanes with 1,3-cyclodiones

RSC Adv. 2023 Mar 7;13(11):7432-7435. doi: 10.1039/d2ra08257h. eCollection 2023 Mar 1.

Authors

Dongxin Zhang¹, Lvjia Chen¹, Huiqing Deng¹, Ying Zhang¹, Qihang Cheng¹, Qian-Feng Zhang¹

Affiliation

¹ Institute of Molecular Engineering and Applied Chemistry, Anhui University of Technology No. 59 Hudong Road Ma'anshan 243002 China dxzhang@ahut.edu.cn zhangqf@ahut.edu.cn.

Abstract

Asymmetric ring-opening reactions of donor-acceptor cyclopropanes with 1,3-cyclodiones have been established for the synthesis of enantioenriched γ-hydroxybutyric acid derivatives in the presence of Cu(ii)/trisoxazoline catalyst. These reactions offered the desired products in 70% to 93% yields with 79% to 99% enantiomeric excesses.