Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives

Haijie Han; Su Li; Mingyu Xu; Yueyang Zhong; Wenjie Fan; Jingwei Xu; Tinglian Zhou; Jian Ji; Juan Ye; Ke Yao

doi:10.1016/j.addr.2023.114770

Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives

Adv Drug Deliv Rev. 2023 May:196:114770. doi: 10.1016/j.addr.2023.114770. Epub 2023 Mar 7.

Authors

Haijie Han¹, Su Li², Mingyu Xu², Yueyang Zhong¹, Wenjie Fan², Jingwei Xu¹, Tinglian Zhou², Jian Ji³, Juan Ye⁴, Ke Yao⁵

Affiliations

¹ Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, People's Republic of China; Zhejiang Provincial Key Lab of Ophthalmology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, People's Republic of China.
² Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, People's Republic of China.
³ MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China.
⁴ Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, People's Republic of China; Zhejiang Provincial Key Lab of Ophthalmology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, People's Republic of China. Electronic address: yejuan@zju.edu.cn.
⁵ Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, People's Republic of China; Zhejiang Provincial Key Lab of Ophthalmology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, People's Republic of China. Electronic address: xlren@zju.edu.cn.

PMID: 36894134
DOI: 10.1016/j.addr.2023.114770

Abstract

Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of over 43 million blindness. However, efficient drug delivery to treat ocular diseases, particularly intraocular disorders, remains a huge challenge due to multiple ocular barriers that significantly affect the ultimate therapeutic efficacy of drugs. Recent advances in nanocarrier technology offer a promising opportunity to overcome these barriers by providing enhanced penetration, increased retention, improved solubility, reduced toxicity, prolonged release, and targeted delivery of the loaded drug to the eyes. This review primarily provides an overview of the progress and contemporary applications of nanocarriers, mainly polymer- and lipid-based nanocarriers, in treating various eye diseases, highlighting their value in achieving efficient ocular drug delivery. Additionally, the review covers the ocular barriers and administration routes, as well as the prospective future developments and challenges in the field of nanocarriers for treating ocular diseases.

Keywords: Lipid-based nanocarrier; Ocular barriers; Ocular diseases; Ocular drug delivery; Polymer-based nanocarrier.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Drug Carriers*
Drug Delivery Systems
Eye
Humans
Lipids
Nanoparticles* / therapeutic use

Substances

Drug Carriers
Lipids