Neuroprotective Effects of N-acetylserotonin and Its Derivative

Neuroscience. 2023 May 1:517:18-25. doi: 10.1016/j.neuroscience.2023.02.017. Epub 2023 Mar 8.

Abstract

N-acetylserotonin (NAS) is a chemical intermediate in melatonin biosynthesis. NAS and its derivative N-(2-(5-hydroxy-1H-indol-3-yl) ethyl)-2-oxopiperidine-3-carboxamide (HIOC) are potential therapeutic agents for traumatic brain injury, autoimmune encephalomyelitis, hypoxic-ischemic encephalopathy, and other diseases. Evidence shows that NAS and its derivative HIOC have neuroprotective properties, and can exert neuroprotective effects by inhibiting oxidative stress, anti-apoptosis, regulating autophagy dysfunction, and anti-inflammatory. In this review, we discussed the neuroprotective effects and related mechanisms of NAS and its derivative HIOC to provide a reference for follow-up research and applications.

Keywords: N-acetylserotonin; apoptosis; inflammation; neuroprotection; oxidative stress.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Encephalomyelitis, Autoimmune, Experimental*
  • Humans
  • Melatonin* / pharmacology
  • Neuroprotection
  • Neuroprotective Agents* / pharmacology
  • Serotonin / pharmacology

Substances

  • N-acetylserotonin
  • Neuroprotective Agents
  • Serotonin
  • Melatonin