Defective porphyrin-based metal-organic framework nanosheets derived from V2CTx MXene as a robust bioplatform for impedimetric aptasensing 17β-estradiol

Jiameng Liu; Mengfei Wang; Chuanpan Guo; Zheng Tao; Minghua Wang; Linghao He; Baozhong Liu; Zhihong Zhang

doi:10.1016/j.foodchem.2023.135839

Defective porphyrin-based metal-organic framework nanosheets derived from V₂CT_x MXene as a robust bioplatform for impedimetric aptasensing 17β-estradiol

Food Chem. 2023 Aug 1:416:135839. doi: 10.1016/j.foodchem.2023.135839. Epub 2023 Mar 5.

Authors

Jiameng Liu¹, Mengfei Wang², Chuanpan Guo², Zheng Tao², Minghua Wang², Linghao He², Baozhong Liu³, Zhihong Zhang⁴

Affiliations

¹ College of Chemistry and Chemical Engineering, Henan Polytechnic University, 2001 Century Avenue, Jiaozuo 454000, PR China.
² College of Material and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, PR China.
³ College of Chemistry and Chemical Engineering, Henan Polytechnic University, 2001 Century Avenue, Jiaozuo 454000, PR China. Electronic address: bzliu@hpu.edu.cn.
⁴ College of Material and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, PR China. Electronic address: 2006025@zzuli.edu.cn.

PMID: 36893636
DOI: 10.1016/j.foodchem.2023.135839

Abstract

An electrochemical aptasensor was prepared for the efficient, sensitive, and selective detection of 17β-estradiol. The sensor was based on a defective two-dimensional porphyrin-based metal-organic framework derived from V₂CT_x MXene. The resulting metal-organic framework nanosheets benefited from the advantages of V₂CT_x MXene nanosheets and porphyrin-based metal-organic framework, two-dimensional porphyrin-based metal-organic framework nanosheets demonstrated amplified electrochemical response and enhanced aptamer-immobilization ability compared with V₂CT_x MXene nanosheets. The sensor's detection limit was ultralow at 0.81 fg mL^-1 (2.97 fM), and the 17β-estradiol concentration range was wide, thereby outperforming most reported aptasensors. The high selectivity, superior stability and reproducibility, and excellent regeneration performance of the constructed aptasensor indicated its remarkable potential application for 17β-estradiol determination in diverse real samples. This aptasensing strategy can be used to analyze other targets by replacing the corresponding aptamer.

Keywords: Detection of 17β-estradiol; Impedimetric aptasensor; Porphyrin-based metal–organic framework; V(2)CT(x) MXene nanosheets.

MeSH terms

Aptamers, Nucleotide*
Biosensing Techniques* / methods
Electrochemical Techniques / methods
Estradiol
Limit of Detection
Metal-Organic Frameworks*
Porphyrins*
Reproducibility of Results
Tomography, X-Ray Computed

Substances

Metal-Organic Frameworks
Porphyrins
MXene
Aptamers, Nucleotide
Estradiol