This report is the first update for the Agency for Healthcare Research and Quality (AHRQ) 2020 report Acute Treatments for Episodic Migraine (available at
The objective of this update is to identify the latest evidence published since the 2020 report and to determine how the new evidence impacts the findings of the 2020 report. Subsequent updates are planned for March 2022 (based on evidence published from October to December 2021) and June 2022 (based on evidence published from January to March 2022).