Lower Energy Excitation of Water Soluble Near-Infrared Emitting Mixed-Ligand Metallacrowns

Tu N Nguyen; Svetlana V Eliseeva; Ivana Martinić; Peggy L Carver; Timothée Lathion; Stéphane Petoud; Vincent L Pecoraro

doi:10.1002/chem.202300226

Lower Energy Excitation of Water Soluble Near-Infrared Emitting Mixed-Ligand Metallacrowns

Chemistry. 2023 May 22;29(29):e202300226. doi: 10.1002/chem.202300226. Epub 2023 Apr 13.

Authors

Tu N Nguyen^{1

2}, Svetlana V Eliseeva³, Ivana Martinić³, Peggy L Carver⁴, Timothée Lathion¹, Stéphane Petoud³, Vincent L Pecoraro¹

Affiliations

¹ Department of Chemistry, Willard H. Dow Laboratories, University of Michigan, Ann Arbor, Michigan, 48109, USA.
² Helen Scientific Research and Technological Development Co., Ltd, Ho Chi Minh City, Vietnam.
³ Centre de Biophysique Moléculaire, CNRS UPR 4301, Rue Charles Sadron, 45071, Orléans Cedex 2, France.
⁴ College of Pharmacy and Michigan Medicine, University of Michigan, Ann Arbor, Michigan, 48109, USA.

PMID: 36892548
DOI: 10.1002/chem.202300226

Abstract

By combining advantages of two series of lanthanide(III)/zinc(II) metallacrowns (MCs) assembled using pyrazine- (pyzHA^2- ) and quinoxaline- (quinoHA^2- ) hydroximate building blocks ligands, we created here water-soluble mixed-ligand MCs with extended absorption to the visible range. The Yb^III analogue demonstrated improved photophysical properties in the near-infrared (NIR) range in cell culture media, facilitating its application for NIR optical imaging in living HeLa cells.

Keywords: lanthanide; luminescence; metallacrown; near-infrared; optical imaging.

Abstract

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