Protection from alcohol intoxication: Must be FGF21 to enter

Martin Jastroch; Susanne Keipert; Matthias H Tschöp

doi:10.1016/j.cmet.2023.02.010

Protection from alcohol intoxication: Must be FGF21 to enter

Cell Metab. 2023 Mar 7;35(3):377-379. doi: 10.1016/j.cmet.2023.02.010.

Authors

Martin Jastroch¹, Susanne Keipert¹, Matthias H Tschöp²

Affiliations

¹ Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden.
² Helmholtz Zentrum München, 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technical University of München, Munich, Germany. Electronic address: matthias.tschoep@helmholtz-muenchen.de.

PMID: 36889276
DOI: 10.1016/j.cmet.2023.02.010

Abstract

Fibroblast growth factor 21 (FGF21) is generally known as a stress-induced metabolic regulator with enormous therapeutic potential to treat metabolic diseases, but a more specific role of FGF21 concerns physiological handling of alcohol in mammals. In this issue of Cell Metabolism, Choi et al. demonstrate that FGF21 mediates the recovery from alcohol intoxication by directly activating noradrenergic neurons in mice, thus advancing our knowledge on FGF21 biology and further diversifying its therapeutic potential.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Alcoholic Intoxication*
Animals
Ethanol
Fibroblast Growth Factors / metabolism
Mammals / metabolism
Metabolic Diseases*
Mice

Substances

fibroblast growth factor 21
Fibroblast Growth Factors
Ethanol