Dual role of polyglycerol vitamin E succinate in emulsions: An efficient antioxidant emulsifier

Yanyan Zhou; Xiang Luo; Zhixin Wang; David Julian McClements; Wenna Huang; Hongliang Fu; Kewu Zhu

doi:10.1016/j.foodchem.2023.135776

Dual role of polyglycerol vitamin E succinate in emulsions: An efficient antioxidant emulsifier

Food Chem. 2023 Aug 1:416:135776. doi: 10.1016/j.foodchem.2023.135776. Epub 2023 Mar 1.

Authors

Yanyan Zhou¹, Xiang Luo², Zhixin Wang¹, David Julian McClements³, Wenna Huang¹, Hongliang Fu¹, Kewu Zhu⁴

Affiliations

¹ Center for Drug Delivery System Research, School of Medicine, Shaoxing University, 900 Chengnan Avenue, Shaoxing, Zhejiang 312000, China.
² Center for Drug Delivery System Research, School of Medicine, Shaoxing University, 900 Chengnan Avenue, Shaoxing, Zhejiang 312000, China; Zhejiang Engineering Research Center of Fat-soluble Vitamin, School of Chemistry and Chemical Engineering, Shaoxing University, 900 Chengnan Avenue, Shaoxing, Zhejiang 312000, China.
³ Biopolymers and Colloids Laboratory, Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
⁴ Center for Drug Delivery System Research, School of Medicine, Shaoxing University, 900 Chengnan Avenue, Shaoxing, Zhejiang 312000, China. Electronic address: kewuzhu@usx.edu.cn.

PMID: 36889015
DOI: 10.1016/j.foodchem.2023.135776

Abstract

α-Tocopherol, as an oil-soluble vitamin with strong antioxidant activity. It is the most naturally abundant and biologically active form of vitamin E in humans. In this study, a novel emulsifier (PG20-VES) was synthesized by attaching hydrophilic twenty-polyglycerol (PG20) to hydrophobic vitamin E succinate (VES). This emulsifier was shown to have a relatively low critical micelle concentration (CMC = 3.2 μg/mL). The antioxidant activities and emulsification properties of PG20-VES were compared with those of a widely used commercial emulsifier: D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS). PG20-VES exhibited a lower interfacial tension, stronger emulsifying capacity and similar antioxidant property to TPGS. An in vitro digestion study showed that lipid droplets coated by PG20-VES were digested under simulated small intestine conditions. This study showed that PG20-VES is an efficient antioxidant emulsifier, which may have applications in the formulation of bioactive delivery systems in the food, supplement, and pharmaceutical industries.

Keywords: Emulsifier; Nanoemulsion; Polyglycerol; TPGS; Vitamin E succinate.

MeSH terms

Antioxidants* / chemistry
Emulsifying Agents / chemistry
Emulsions
Humans
Polyethylene Glycols / chemistry
Polymers
Vitamin E / chemistry
alpha-Tocopherol* / chemistry

Substances

Antioxidants
alpha-Tocopherol
polyglycerol
Emulsions
Vitamin E
Polymers
Polyethylene Glycols
Emulsifying Agents