The Role of Bone Morphogenetic Protein 4 in Lung Diseases

Abstract

Bone morphogenetic protein 4 (BMP4) is a multifunctional secretory protein that belongs to the transforming growth factor β superfamily. BMPs transduce their signaling to the cytoplasm by binding to membrane receptors of the serine/threonine kinase family, including BMP type I and type II receptors. BMP4 participates in various biological processes, such as embryonic development, epithelial-mesenchymal transition, and maintenance of tissue homeostasis. The interaction between BMP4 and the corresponding endogenous antagonists plays a key role in the precise regulation of BMP4 signaling. In this paper, we review the pathogenesis of BMP4-related lung diseases and the foundation on which BMP4 endogenous antagonists have been developed as potential targets.

Keywords: Bone morphogenetic protein 4; asthma; chronic obstructive pulmonary disease; congenital pulmonary airway malformation; endogenous antagonists; non-small cell lung cancer; pulmonary artery hypertension; pulmonary fibrosis.