FRC-derived retinoic acid: The key to unlocking milky spots

J Exp Med. 2023 May 1;220(5):e20230157. doi: 10.1084/jem.20230157. Epub 2023 Mar 6.

Abstract

Milky spots of the omentum enable lymphocyte access to the peritoneal cavity. In this issue of JEM, Yoshihara and Okabe (2023. J. Exp. Med.https://doi.org/10.1084/jem.20221813) demonstrate how secretion of retinoic acid by fibroblastic reticular cells allows lymphocyte entry into milky spots and the peritoneal cavity.

Publication types

  • Comment

MeSH terms

  • Omentum*
  • Peritoneal Cavity*
  • Tretinoin

Substances

  • Tretinoin