Participation in a clinical trial is associated with lower mortality but not lower risk of HF hospitalization in patients with heart failure: observations from the ESC EORP Heart Failure Long-Term Registry

Chris J Kapelios; Lina Benson; Maria G Crespo-Leiro; Stefan D Anker; Andrew J S Coats; Ovidiu Chioncel; Gerasimos Filippatos; Mitja Lainscak; Theresa McDonagh; Alexandre Mebazaa; Marco Metra; Massimo F Piepoli; Giuseppe M C Rosano; Frank Ruschitzka; Gianluigi Savarese; Petar M Seferovic; Maurizio Volterrani; Aldo P Maggioni; Lars H Lund

doi:10.1093/eurheartj/ehad109

Participation in a clinical trial is associated with lower mortality but not lower risk of HF hospitalization in patients with heart failure: observations from the ESC EORP Heart Failure Long-Term Registry

Eur Heart J. 2023 May 1;44(17):1526-1529. doi: 10.1093/eurheartj/ehad109.

Authors

Chris J Kapelios¹, Lina Benson², Maria G Crespo-Leiro³, Stefan D Anker⁴, Andrew J S Coats⁵, Ovidiu Chioncel⁶, Gerasimos Filippatos⁷, Mitja Lainscak⁸, Theresa McDonagh⁹, Alexandre Mebazaa¹⁰, Marco Metra¹¹, Massimo F Piepoli¹², Giuseppe M C Rosano¹³, Frank Ruschitzka¹⁴, Gianluigi Savarese², Petar M Seferovic¹⁵, Maurizio Volterrani^{16

17}, Aldo P Maggioni¹⁸, Lars H Lund²

Affiliations

¹ Department of Cardiology, Laiko General Hospital, Athens, Greece.
² Unit of Cardiology, Department of Medicine, Karolinska Institutet, Solna, S1:02, 171 76 Stockholm, Sweden.
³ Unidad de Insuficiencia Cardiaca Avanzada y Trasplante Cardiaco, Complexo Hospitalario Universitario A Coruna, CHUAC, INIBIC, UDC, CIBERCV, La Coruna, Spain.
⁴ Department of Cardiology (CVK), Berlin Institute of Health Center for Regenerative Therapies (BCRT), and German Centre for Cardiovascular Research (DZHK) Partner Site Berlin, Charité Universitätsmedizin, Berlin, Germany.
⁵ Heart Research Institute, Sydney, Australia.
⁶ Emergency Institute for Cardiovascular Diseases 'Prof. C.C. Iliescu', University of Medicine Carol Davila, Bucharest, Romania.
⁷ Heart Failure Unit, Department of Cardiology, University Hospital Attikon, National and Kapodistrian University of Athens, Athens, Greece.
⁸ Division of Cardiology, Murska Sobota, Murska Sobota and Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
⁹ King's College Hospital, London, UK.
¹⁰ Department of Anesthesia-Burn-Critical Care, UMR 942 Inserm-MASCOT, University of Paris, APHP Saint Louis Lariboisière University Hospitals, Paris, France.
¹¹ Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
¹² Clinical Cardiology, IRCCS Policlinico San Donato Milanese, Milan, Italy.
¹³ IRCCS San Raffaele Pisana, Rome, Italy.
¹⁴ Clinic of Cardiology, University Hospital, Zürich, Switzerland.
¹⁵ Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
¹⁶ Department of Human Science and Promotion of Quality of Life, San Raffaele Open University of Rome, Rome, Italy.
¹⁷ Cardiopulmonary Department, IRCCS San Raffaele, Rome, Italy.
¹⁸ ANMCO Research Center, Heart Care Foundation, Florence, Italy.

No abstract available

Keywords: Clinical trial; Heart failure; Heart failure hospitalization; Mildly reduced ejection fraction; Mortality; Outcomes; Preserved ejection fraction; Randomized controlled trial; Reduced ejection fraction; Registry; Trial design.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Heart Failure* / therapy
Hospitalization
Humans
Registries
Stroke Volume
Ventricular Function, Left