Nano cellulose-laden alginate/chitosan sponge with enhanced biological and hemostatic behavior

Garima Tripathi; Jaegyoung Gwon; Byong Taek Lee

doi:10.1080/09205063.2023.2187985

Nano cellulose-laden alginate/chitosan sponge with enhanced biological and hemostatic behavior

J Biomater Sci Polym Ed. 2023 Oct;34(13):1813-1823. doi: 10.1080/09205063.2023.2187985. Epub 2023 Mar 28.

Authors

Garima Tripathi¹, Jaegyoung Gwon², Byong Taek Lee^{1

3}

Affiliations

¹ Institute of Tissue Regeneration, Soonchunhyang University, Cheonan, South Korea.
² Division of Environmental Material Engineering, Department of Forest Products, Korea Forest Research Institute, Seoul, South Korea.
³ Department of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan, South Korea.

PMID: 36877157
DOI: 10.1080/09205063.2023.2187985

Abstract

Present study describes about hybrid hemostat developed with alginate (Alg), chitosan (Chito) and TEMPO-oxidized nanofibrillar cellulose (TOCNF) via lyophilization. All samples were analyzed under scanning electron microscopy (SEM) to determine their microstructure, size, and distribution of pores. Cell viability and proliferation of the scaffolds tested using fibroblast type L929 cells, showed it to be an excellent medium for cell generation. Blood coagulation started in ∼7.5 min, and most of the fibrin network formation took place in the Alg-Chito-TOCNF sponge, making it a suitable hemostatic material.

Keywords: Nano cellulose; alginate; hemostat; scaffold.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alginates / chemistry
Cellulose / chemistry
Cellulose, Oxidized*
Chitosan* / chemistry
Hemostatics* / pharmacology
Tissue Scaffolds / chemistry

Substances

Chitosan
Hemostatics
Alginates
Cellulose
Cellulose, Oxidized