Ferroptosis has gained interest due to it immunogenicity and the higher sensitivity of cancer cells to it. However, it was recently shown that ferroptosis in tumor-associated neutrophils leads to immunosuppression and negatively impacts therapy. Here, we discuss the potential implications of the two sides (friend versus foe) of ferroptosis in cancer immunotherapy.
Keywords: Immunogenic cell death; cancer immunosuppression; immunogenic ferroptosis.
© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.