The roles of COX-2 in protozoan infection

Xinlei Wang; Jie Chen; Jingtong Zheng

doi:10.3389/fimmu.2023.955616

The roles of COX-2 in protozoan infection

Front Immunol. 2023 Feb 16:14:955616. doi: 10.3389/fimmu.2023.955616. eCollection 2023.

Authors

Xinlei Wang¹, Jie Chen², Jingtong Zheng³

Affiliations

¹ Department of Clinical Laboratory, The Second Hospital of Jilin University, Jilin University, Changchun, China.
² Institute of Theoretical Chemistry, Jilin University, Changchun, China.
³ Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University, Changchun, China.

Abstract

Protozoan diseases cause great harm in animal husbandry and require human-provided medical treatment. Protozoan infection can induce changes in cyclooxygenase-2 (COX-2) expression. The role played by COX-2 in the response to protozoan infection is complex. COX-2 induces and regulates inflammation by promoting the synthesis of different prostaglandins (PGs), which exhibit a variety of biological activities and participate in pathophysiological processes in the body in a variety of ways. This review explains the roles played by COX-2 in protozoan infection and analyzes the effects of COX-2-related drugs in protozoan diseases.

Keywords: AA; COX-2; PGs; protozoa; protozoan infection.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animal Husbandry
Animals
Cyclooxygenase 2
Humans
Inflammation
Prostaglandins
Protozoan Infections*

Substances

Cyclooxygenase 2
Prostaglandins

Grants and funding

This work was supported by the Bethune Research Plan of Jilin University (grant number: 2020-31), the Training Plan for Lixin Excellent Young Teachers of Jilin University (grant number: 2021) and the Foundation of Jilin Provincial Department of Education (grant number: JJKH20201026KJ). Jilin Provincial Science and Technology Development Plan, 20200202046YY (Which belongs to JZ).