Emerging role of interaction between m6A and main ncRNAs in gastrointestinal (GI) cancers

Front Immunol. 2023 Feb 17:14:1129298. doi: 10.3389/fimmu.2023.1129298. eCollection 2023.

Abstract

As a prevalent epigenetic modification, the role of m6A has been increasingly highlighted in the alteration of numerous RNAs implicated with multiple biological processes, such as formation, export, translation, and degradation. With further the understanding of m6A, accumulating evidence shows that m6A modification similarly affects metabolic process of non-coding genes. But the specifical interplay of m6A and ncRNAs (non-coding RNAs) in gastrointestinal cancers still lacks complete discussion. Thus, we analyzed and summarized how ncRNAs affect the regulators of m6A and by what means the expression of ncRNAs is altered via m6A in gastrointestinal cancers. We focused on the effect of the interaction of m6A and ncRNAs on the molecular mechanisms of malignant behavior in gastrointestinal cancers, revealing more possibilities of ncRNAs for diagnosis and treatment in term of epigenetic modification.

Keywords: circRNA; gastrointestinal cancers; lncRNA; m6A; miRNA.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Epigenesis, Genetic
  • Gastrointestinal Neoplasms*
  • Humans
  • RNA
  • RNA, Untranslated*

Substances

  • RNA, Untranslated
  • RNA

Grants and funding

This work was funded by the National Natural Science Foundation of China (819028328), Leading Talents of Zhongyuan Science and Technology Innovation (214200510027), Henan Provincial Medical Science and Technology Research Plan (SBGJ2018002 and SBGJ202102117), Science and Technology Innovation Talents in Henan Universities (19HASTIT003), the Gandan Xiangzhao Research Fund (GDXZ2022002), Outstanding Foreign Scientist Studio in Henan Province (GZS2020004) and Henan Provincial Department of Science and Technology Research on Science and Technology (222102310365).