The synthesis and highly effective antibacterial properties of Cu-3, 5-dimethy l-1, 2, 4-triazole metal organic frameworks

Xiaolin Xu; Mengna Ding; Kaiquan Liu; Fujian Lv; Yingchun Miao; Yanmi Liu; Ying Gong; Yuning Huo; Hexing Li

doi:10.3389/fchem.2023.1124303

The synthesis and highly effective antibacterial properties of Cu-3, 5-dimethy l-1, 2, 4-triazole metal organic frameworks

Front Chem. 2023 Feb 15:11:1124303. doi: 10.3389/fchem.2023.1124303. eCollection 2023.

Authors

Xiaolin Xu¹, Mengna Ding¹, Kaiquan Liu¹, Fujian Lv¹, Yingchun Miao¹, Yanmi Liu¹, Ying Gong¹, Yuning Huo², Hexing Li²

Affiliations

¹ Faculty of Chemical and Environmental Science, Key Laboratory of Environment Chemistry, Qujing Normal University, Qujing, Yunnan, China.
² The Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry, Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Frontiers Science Research Base of Biomimetic Catalysis, and College of Chemistry and Materials Science, Shanghai Frontiers Science Center of Biomimetic Catalysis, Shanghai Normal University, Shanghai, China.

Abstract

The influence of metal ions, the state of metal salt, and ligands on the sterilization ability of (Metalorganic frameworks) MOFs to effectively achieve sterilization has been investigated in this study. Initially, the MOFs were synthesized by elements of Zn, Ag, and Cd for the same periodic and main group of Cu. This illustrated that the atomic structure of Cu was more beneficial for coordinating with ligands. To further induce the maximum amount of Cu²⁺ ions in the Cu-MOFs to achieve the highest sterilization, various Cu-MOFs synthesized by the different valences of Cu, various states of copper salts, and organic ligands were performed, respectively. The results demonstrated that Cu-MOFs synthesized by 3, 5-dimethyl-1, 2, 4-triazole and tetrakis (acetonitrile) copper(I) tetrafluoroborate presented the largest inhibition-zone diameter of 40.17 mm towards Staphylococcus Aureus (S. aureus) under dark conditions. The proposed mechanism of Cu (Ⅱ) in MOFs could significantly cause multiple toxic effects, such as the generation of reactive oxygen species, and lipid peroxidation in S. aureus cells, when the bacteria was anchored by the Cu-MOFs via electrostatic interaction. Finally, the broad antimicrobial properties of Cu-MOFs against Escherichia coli (E. coli), Acinetobacter baumannii (A. baumannii), and S. aureus were demonstrated. In conclusion, the Cu-3, 5-dimethyl-1, 2, 4-triazole MOFs appeared to be potential antibacterial catalysts in the antimicrobial field.

Keywords: Cu-3,5-dimethyl-1,2,4-triazole MOFs; Staphylococcus Aureus; electrostatic interaction; inhibition-zone diameter; sterilization.

Grants and funding

This work was supported by the Scientific and Technological Innovation Team for Green Catalysis and Energy Materialien Yunnan Institutions of Higher Learning, International Joint Laboratory on Resource Chemistry SHNU-NUS-PU, Resource Chemistry Key Laboratory of Ministry of Education and Shanghai Normal University, Surface project of Yunnan Province science and technology Department (20210 A070001-050), Ministry of Education of China (PCSIRT_IRT_16R49), “111” Innovation and Talent Recruitment Base on Photochemical and Energy Materials (No. D18020), Shanghai Government (20ZR1440700), and Shanghai Engineering Research Center of Green Energy Chemical Engineering (No. 18DZ2254200).