Synthesis of Difluoroarymethyl-Substituted Benzimidazo[2,1- a]isoquinolin-6(5 H)-ones under Mild Conditions

Kaixia Sui; Yuting Leng; Yangjie Wu

doi:10.1021/acsomega.2c06689

Synthesis of Difluoroarymethyl-Substituted Benzimidazo[2,1- a]isoquinolin-6(5 H)-ones under Mild Conditions

ACS Omega. 2023 Feb 14;8(8):7517-7528. doi: 10.1021/acsomega.2c06689. eCollection 2023 Feb 28.

Authors

Kaixia Sui¹, Yuting Leng¹, Yangjie Wu¹

Affiliation

¹ Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450052, P. R. China.

Abstract

A highly efficient method for synthesis of difluoroarymethyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-ones using 2-arylbenzoimidazoles with α,α-difluorophenylacetic acid as reaction substrates has been developed through radical cascade cyclization. The advantage of this strategy lies in excellent functional group tolerance to generate the corresponding products in good yields under base- and metal-free conditions.