Atomic-Level Regulation of Cobalt Single-Atom Nanozymes: Engineering High-Efficiency Catalase Mimics

Yuanjun Chen; Bing Jiang; Haigang Hao; Haijing Li; Chenyue Qiu; Xiao Liang; Qingyun Qu; Zedong Zhang; Rui Gao; Demin Duan; Shufang Ji; Dingsheng Wang; Minmin Liang

doi:10.1002/anie.202301879

Atomic-Level Regulation of Cobalt Single-Atom Nanozymes: Engineering High-Efficiency Catalase Mimics

Angew Chem Int Ed Engl. 2023 May 2;62(19):e202301879. doi: 10.1002/anie.202301879. Epub 2023 Mar 24.

Authors

Yuanjun Chen^{1

2}, Bing Jiang³, Haigang Hao⁴, Haijing Li⁵, Chenyue Qiu⁶, Xiao Liang¹, Qingyun Qu¹, Zedong Zhang¹, Rui Gao⁴, Demin Duan⁷, Shufang Ji⁸, Dingsheng Wang¹, Minmin Liang³

Affiliations

¹ Department of Chemistry, Tsinghua University, Beijing, 100084, China.
² Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario, M5S1A4, Canada.
³ Experimental Center of Advanced Materials, School of Materials Science & Engineering, Beijing Institute of Technology, Beijing, 100081, China.
⁴ College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, China.
⁵ Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
⁶ Department of Materials Science and Engineering, University of Toronto, Toronto, Ontario, M5S3E4, Canada.
⁷ CAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academic of Science, Beijing, 100101, China.
⁸ Department of Chemistry, University of Toronto, Ontario, M5S3H6, Canada.

PMID: 36872618
DOI: 10.1002/anie.202301879

Abstract

Nanozymes aim to mimic the highly evolved active centers of natural enzymes. Despite progress in nanozyme engineering, their catalytic performance is much less favorable compared with natural enzymes. This study shows that precise control over the atomic configuration of the active centers of Co single-atom nanozymes (SAzymes) enables the rational regulation of their catalase-like performance guided by theorical calculations. The constructed Co-N₃ PS SAzyme exhibits an excellent catalase-like activity and kinetics, exceeding the representative controls of Co-based SAzymes with different atomic configurations. Moreover, we developed an ordered structure-oriented coordination design strategy for rationally engineering SAzymes and established a correlation between the structure and enzyme-like performance. This work demonstrates that precise control over the active centers of SAzymes is an efficient strategy to mimic the highly evolved active sites of natural enzymes.

Keywords: Atomic-Level Regulation; Catalase Mimics; Co Single-Atom; Nanozymes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomimetic Materials / chemistry
Carbon* / chemistry
Catalase
Catalysis
Cobalt / chemistry

Substances

Carbon
Catalase
Cobalt