Posterior Staphyloma as Determining Factor for Myopic Maculopathy

José M Ruiz-Moreno; Mariluz Puertas; Ignacio Flores-Moreno; Elena Almazán-Alonso; María García-Zamora; Jorge Ruiz-Medrano

doi:10.1016/j.ajo.2023.02.017

Posterior Staphyloma as Determining Factor for Myopic Maculopathy

Am J Ophthalmol. 2023 Aug:252:9-16. doi: 10.1016/j.ajo.2023.02.017. Epub 2023 Mar 2.

Authors

José M Ruiz-Moreno¹, Mariluz Puertas², Ignacio Flores-Moreno³, Elena Almazán-Alonso⁴, María García-Zamora⁴, Jorge Ruiz-Medrano⁵

Affiliations

¹ Puerta de Hierro-Majadahonda University Hospital (J.M.R.-M., M.P., I.F.-M., E.A.-A., M.G-Z., J.R.-M), Madrid, Spain; Department of Ophthalmology (J.M.R.-M.), Castilla La Mancha University, Albacete, Spain; Miranza Corporation (J.M.R.-M., J.R.-M), Madrid, Spain.
² Puerta de Hierro-Majadahonda University Hospital (J.M.R.-M., M.P., I.F.-M., E.A.-A., M.G-Z., J.R.-M), Madrid, Spain. Electronic address: mariluzpuertas@gmail.com.
³ Puerta de Hierro-Majadahonda University Hospital (J.M.R.-M., M.P., I.F.-M., E.A.-A., M.G-Z., J.R.-M), Madrid, Spain; Clínica Suárez Leoz (I.F.-M.), Madrid, Spain.
⁴ Puerta de Hierro-Majadahonda University Hospital (J.M.R.-M., M.P., I.F.-M., E.A.-A., M.G-Z., J.R.-M), Madrid, Spain.
⁵ Puerta de Hierro-Majadahonda University Hospital (J.M.R.-M., M.P., I.F.-M., E.A.-A., M.G-Z., J.R.-M), Madrid, Spain; Miranza Corporation (J.M.R.-M., J.R.-M), Madrid, Spain.

PMID: 36868340
DOI: 10.1016/j.ajo.2023.02.017

Abstract

Purpose: The aim of this study was to determine the influence of posterior staphyloma (PS) on the development of myopic maculopathy.

Design: Cross-sectional study.

Methods: A total of 467 highly myopic eyes (axial length [AL] ≥26 mm) of 246 patients were included. Patients underwent a complete ophthalmological examination, including multimodal imaging. Presence of PS was defined as the main variable analyzed between groups (PS vs non-PS): age, AL, best-corrected visual acuity (BCVA), atrophy/traction/neovascularization (ATN) components, and presence of severe pathologic myopia (PM). Two different cohorts were studied (age-matched and AL-matched) comparing PS vs non-PS eyes.

Results: In all, 325 eyes (69.59%) presented with PS. Eyes without PS were younger and had lower AL, ATN components, and prevalence of severe PM than those with PS (P < .001). Moreover, non-PS eyes had better BCVA (P < .001). Analyzing the age-matched cohort (P = .96); mean AL, A, and T components, and severe PM were significantly higher in the PS group (P < .001), as well as the N component (P < .005), showing worse BCVA (P < .001). Regarding the AL-matched cohort (P = .93), the PS group showed worse BCVA (P < .01), older age (P < .001), A (P < .001), and T components (P < .01), and severe PM (P < .01). The risk of PS increased by 10% per year of age (odds ratio = 1.109, P < .001) and by 132% per each millimeter of growth of AL (odds ratio = 2.318, P < .001).

Conclusions: Posterior staphyloma is associated with myopic maculopathy, worse visual acuity, and higher prevalence of severe PM. AL and age, in this order, constitute the main factors associated with the onset of PS.

MeSH terms

Cross-Sectional Studies
Eye
Humans
Macular Degeneration* / complications
Myopia, Degenerative* / complications
Myopia, Degenerative* / diagnosis
Myopia, Degenerative* / pathology
Retinal Diseases* / complications
Retinal Diseases* / etiology
Retrospective Studies
Scleral Diseases* / diagnosis
Tomography, Optical Coherence
Vision Disorders / complications