Recent structural advances in bacterial chemotaxis signalling

Carlos Riechmann; Peijun Zhang

doi:10.1016/j.sbi.2023.102565

Recent structural advances in bacterial chemotaxis signalling

Curr Opin Struct Biol. 2023 Apr:79:102565. doi: 10.1016/j.sbi.2023.102565. Epub 2023 Mar 1.

Authors

Carlos Riechmann¹, Peijun Zhang²

Affiliations

¹ Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
² Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK; Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, OX3 7BN, UK. Electronic address: peijun.zhang@strubi.ox.ac.uk.

Abstract

Bacterial chemosensory arrays have served as a model system for in-situ structure determination, clearly cataloguing the improvement of cryo-electron tomography (cryoET) over the past decade. In recent years, this has culminated in an accurately fitted atomistic model for the full-length core signalling unit (CSU) and numerous insights into the function of the transmembrane receptors responsible for signal transduction. Here, we review the achievements of the latest structural advances in bacterial chemosensory arrays and the developments which have made such advances possible.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Proteins* / chemistry
Chemotaxis* / physiology
Histidine Kinase / chemistry
Signal Transduction / physiology

Substances

Bacterial Proteins
Histidine Kinase

Abstract

Publication types

MeSH terms

Substances

Grants and funding