A comprehensive overview of PPM1B: From biological functions to diseases

Zhongyao Li; Ruoyu Chen; Yanxia Li; Qian Zhou; Huanxin Zhao; Kewu Zeng; Baobing Zhao; Zhiyuan Lu

doi:10.1016/j.ejphar.2023.175633

A comprehensive overview of PPM1B: From biological functions to diseases

Eur J Pharmacol. 2023 May 15:947:175633. doi: 10.1016/j.ejphar.2023.175633. Epub 2023 Mar 1.

Authors

Zhongyao Li¹, Ruoyu Chen², Yanxia Li², Qian Zhou², Huanxin Zhao¹, Kewu Zeng³, Baobing Zhao⁴, Zhiyuan Lu⁵

Affiliations

¹ School of Pharmacy and Pharmaceutical Sciences, Institute of Materia Medica, Shandong First Medical University, Shandong Academy of Medical Sciences, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji'nan, 250117, Shandong, China.
² Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Ji'nan, 250012, Shandong, China.
³ School of Pharmacy and Pharmaceutical Sciences, Institute of Materia Medica, Shandong First Medical University, Shandong Academy of Medical Sciences, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji'nan, 250117, Shandong, China. Electronic address: ZKW@bjmu.edu.cn.
⁴ Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Ji'nan, 250012, Shandong, China; Department of Pharmacology, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Ji'nan, 250012, Shandong, China; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Ji'nan, 250012, Shandong, China. Electronic address: baobingzh@sdu.edu.cn.
⁵ School of Pharmacy and Pharmaceutical Sciences, Institute of Materia Medica, Shandong First Medical University, Shandong Academy of Medical Sciences, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji'nan, 250117, Shandong, China. Electronic address: luzhiyuan@sdfmu.edu.cn.

PMID: 36863552
DOI: 10.1016/j.ejphar.2023.175633

Abstract

Reversible phosphorylation of proteins is an important mechanism that regulates cellular processes, which are precisely regulated by protein kinases and phosphatases. PPM1B is a metal ion-dependent serine/threonine protein phosphatase, which regulates multiple biological functions by targeting substrate dephosphorylation, such as cell cycle, energy metabolism, inflammatory responses. In this review, we summarized the occurrent understandings of PPM1B focused on its regulation of signaling pathways, related diseases, and small-molecular inhibitors, which may provide new insights for the identification of PPM1B inhibitors and the treatment of PPM1B-related diseases.

Keywords: Biological function; Disease; PPM1B; Protein phosphatase.

Publication types

Review

MeSH terms

Phosphoprotein Phosphatases* / metabolism
Phosphorylation
Protein Kinases / metabolism
Protein Phosphatase 2C
Signal Transduction*

Substances

Protein Phosphatase 2C
Phosphoprotein Phosphatases
Protein Kinases