A Rare Case of Radiation-Associated Aortic and Mitral Valve Stenosis Treated With Transcatheter Valve Replacements

Logan S Schwarzman; Nichelle Megowan; Venkat S Manubolu; Sonia U Shah

doi:10.1016/j.jaccas.2022.08.049

A Rare Case of Radiation-Associated Aortic and Mitral Valve Stenosis Treated With Transcatheter Valve Replacements

JACC Case Rep. 2022 Nov 3:8:101672. doi: 10.1016/j.jaccas.2022.08.049. eCollection 2023 Feb 15.

Authors

Logan S Schwarzman¹, Nichelle Megowan¹, Venkat S Manubolu², Sonia U Shah^{1

2}

Affiliations

¹ Division of Cardiology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA.
² The Lundquist Institute, Torrance, California, USA.

Abstract

Radiation therapy is the standard of care for achieving cure for many thoracic malignancies, but it can result in long-term cardiovascular sequelae such as valve disease. We describe a rare case of severe aortic and mitral stenosis due to prior radiation therapy for giant cell tumor treated successfully with percutaneous aortic and off-label mitral valve replacements. (Level of Difficulty: Intermediate.).

Keywords: AV, aortic valve; CT, computed tomography; LVOT, left ventricular outflow tract; MV, mitral valve; TAVR, transcatheter aortic valve replacement; TMVR, transcatheter mitral valve replacement; TTE, transthoracic echocardiography; aortomitral curtain; radiation therapy; valve stenosis.

Publication types

Case Reports