Mitochondrial dynamics in vascular remodeling and target-organ damage

Tong Zhu; Qingxun Hu; Yanggang Yuan; Huijuan Yao; Jian Zhang; Jia Qi

doi:10.3389/fcvm.2023.1067732

Mitochondrial dynamics in vascular remodeling and target-organ damage

Front Cardiovasc Med. 2023 Feb 13:10:1067732. doi: 10.3389/fcvm.2023.1067732. eCollection 2023.

Authors

Tong Zhu¹, Qingxun Hu^{2

3}, Yanggang Yuan⁴, Huijuan Yao¹, Jian Zhang¹, Jia Qi¹

Affiliations

¹ Department of Pharmacy, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University, School of Medicine, Shanghai University, Shanghai, China.
³ Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai, China.
⁴ Department of Nephrology, The First Hospital Affiliated to Nanjing Medical University, Nanjing, China.

Abstract

Vascular remodeling is the pathological basis for the development of many cardiovascular diseases. The mechanisms underlying endothelial cell dysfunction, smooth muscle cell phenotypic switching, fibroblast activation, and inflammatory macrophage differentiation during vascular remodeling remain elusive. Mitochondria are highly dynamic organelles. Recent studies showed that mitochondrial fusion and fission play crucial roles in vascular remodeling and that the delicate balance of fusion-fission may be more important than individual processes. In addition, vascular remodeling may also lead to target-organ damage by interfering with the blood supply to major body organs such as the heart, brain, and kidney. The protective effect of mitochondrial dynamics modulators on target-organs has been demonstrated in numerous studies, but whether they can be used for the treatment of related cardiovascular diseases needs to be verified in future clinical studies. Herein, we summarize recent advances regarding mitochondrial dynamics in multiple cells involved in vascular remodeling and associated target-organ damage.

Keywords: cardiovascular diseases; fission; fusion; mitochondrial dynamics; target-organ damage; vascular remodeling.

Publication types

Review

Grants and funding

This work was supported by the Shanghai Science and Technology Commission of China (21ZR1441300) and the National Natural Science Foundation of China (81302768, 81870469, and 82170699).