Effects of low-dose furosemide combined with aminophylline on the renal function in septic shock patients

Zhenhua Mai; Yaying Tan; Yang Zhu; Zilong Yang; Hongpeng Chen; Shuting Cai; Wangwang Hu; Xiaoyan Wang; Fenghua Ding; Liehua Deng

doi:10.1080/0886022X.2023.2185084

Effects of low-dose furosemide combined with aminophylline on the renal function in septic shock patients

Ren Fail. 2023 Dec;45(1):2185084. doi: 10.1080/0886022X.2023.2185084.

Authors

Zhenhua Mai^{1

2}, Yaying Tan¹, Yang Zhu¹, Zilong Yang¹, Hongpeng Chen¹, Shuting Cai¹, Wangwang Hu¹, Xiaoyan Wang¹, Fenghua Ding¹, Liehua Deng^{1

2}

Affiliations

¹ Department of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
² Zhanjiang Key Laboratory of Organ Injury and Protection and Translational Medicine, Guangdong, China.

Abstract

Background: To investigate the effects of low-dose furosemide and aminophylline on the renal function in patients with septic shock.

Methods and results: A total of 109 eligible septic shock patients in the intensive care unit were randomly divided into a control group (n = 55) and an intervention group (n = 54). The control group received normal saline, and the intervention group received low-dose furosemide (0.048 mg/kg.h^-1) with aminophylline (0.3 mg/kg.h^-1). The primary outcomes included the levels of serum creatinine (Scr), creatinine clearance rate (Ccr), blood urea nitrogen (BUN), glomerular filtration rate (GFR), and urine output on admission and on days 3, 7 and 14. The secondary outcomes were the sequential organ failure assessment (SOFA) scores, continuous renal replacement therapy (CRRT) time and intensive care unit (ICU) mortality, hospital mortality and 28-day mortality. There were no significant differences in the levels of Scr, Ccr, BUN, or GFR between the two groups, while the urine output was higher in the intervention group on days 3, 7, and 14. Compared with the control group, the SOFA scores, ICU mortality, hospital mortality and 28-day mortality were significantly lower in the intervention group on days 3, 7, and 14, the CRRT time was shorter, and the cumulative fluid balance was lower on days 3 and 7 in the intervention group.

Conclusions: Although low-dose furosemide and aminophylline have fewer protective effects on the renal function in septic shock patients, they could reduce the CRRT time and improve the prognosis.

Keywords: Septic shock; acute kidney injury; aminophylline; furosemide; mortality.

Publication types

Randomized Controlled Trial

MeSH terms

Aminophylline*
Furosemide
Glomerular Filtration Rate
Humans
Kidney / physiology
Shock, Septic* / drug therapy

Substances

Aminophylline
Furosemide

Grants and funding

This work was supported by the Guangdong Medical Science and Technology Research Fund [No. A2015366] and a grant from the National Natural Science Foundation of China [No. 81974298]. The authors’ work was supported by the grants from Guangdong Science and Technology Innovation Strategy Special Fund [No. 2020A1111350047 and No. 2020A1111350049].