The Host Non-Coding RNA Response to Alphavirus Infection

Viruses. 2023 Feb 18;15(2):562. doi: 10.3390/v15020562.

Abstract

Alphaviruses are important human and animal pathogens that can cause a range of debilitating symptoms and are found worldwide. These include arthralgic diseases caused by Old-World viruses and encephalitis induced by infection with New-World alphaviruses. Non-coding RNAs do not encode for proteins, but can modulate cellular response pathways in a myriad of ways. There are several classes of non-coding RNAs, some more well-studied than others. Much research has focused on the mRNA response to infection against alphaviruses, but analysis of non-coding RNA responses has been more limited until recently. This review covers what is known regarding host cell non-coding RNA responses in alphavirus infections and highlights gaps in the knowledge that future research should address.

Keywords: RNA; alphavirus; chikungunya; encephalitis; lncRNA; miRNA; noncoding; snoRNA.

Publication types

  • Review
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alphavirus Infections*
  • Alphavirus* / genetics
  • Animals
  • Arthralgia
  • Encephalitis*
  • Humans
  • RNA, Untranslated / genetics

Substances

  • RNA, Untranslated

Grants and funding

This research was funded by the Defense Threat Reduction Agency (HDTRA-1-20-1-0015 (SB)). The content of the information does not necessarily reflect the position or the policy of the federal government, and no official endorsement should be inferred.