Autophagy and kidney aging

Satoshi Minami; Takeshi Yamamoto; Hitomi Yamamoto-Imoto; Yoshitaka Isaka; Maho Hamasaki

doi:10.1016/j.pbiomolbio.2023.02.005

Autophagy and kidney aging

Prog Biophys Mol Biol. 2023 May:179:10-15. doi: 10.1016/j.pbiomolbio.2023.02.005. Epub 2023 Feb 26.

Authors

Satoshi Minami¹, Takeshi Yamamoto², Hitomi Yamamoto-Imoto¹, Yoshitaka Isaka², Maho Hamasaki³

Affiliations

¹ Department of Genetics, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
² Department of Nephrology, Graduate School of Medicine, Osaka University, Osaka, Japan.
³ Department of Genetics, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan; Department of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan. Electronic address: hamasaki@fbs.osaka-u.ac.jp.

PMID: 36849016
DOI: 10.1016/j.pbiomolbio.2023.02.005

Abstract

Autophagy is a highly conserved intracellular degradation system in eukaryotes that maintains cellular and tissue homeostasis. Upon autophagy induction, cytoplasmic components are engulfed by a double-membrane organelle called the autophagosome that fuses with a lysosome to degrade its contents. In recent years, it has become clear that autophagy becomes dysregulated with aging, which leads to age-related diseases. Kidney function is particularly prone to age-related decline, and aging is the most significant risk factor for chronic kidney disease. This review first discuss the relationship between autophagy and kidney aging. Second, we describe how age-related dysregulation of autophagy occurs. Finally, we discuss the potential of autophagy-targeting drugs to ameliorate human kidney aging and the approaches necessary to discover such agents.

Keywords: Autophagy; Chronic kidney disease; Kidney aging; Lysosome.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aging
Autophagosomes / metabolism
Autophagy*
Humans
Kidney*
Organelles