Immune-metabolic mechanisms of post-traumatic stress disorder and atherosclerosis

Yali Tian; Hanif Ullah; Jun Gu; Ka Li

doi:10.3389/fphys.2023.1123692

Immune-metabolic mechanisms of post-traumatic stress disorder and atherosclerosis

Front Physiol. 2023 Feb 8:14:1123692. doi: 10.3389/fphys.2023.1123692. eCollection 2023.

Authors

Yali Tian¹, Hanif Ullah¹, Jun Gu², Ka Li¹

Affiliations

¹ West China School of Nursing/West China Hospital, Sichuan University, Chengdu, China.
² Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China.

Abstract

The interaction of post-traumatic stress disorder (PTSD) and atherosclerosis (AS) increase the risk of mortality. Metabolism and immunity play important roles in the comorbidity associated with PTSD and AS. The adenosine monophosphate-activated protein kinase/mammalian target of rapamycin and phosphatidylinositol 3-kinase/Akt pathways are attractive research topics in the fields of metabolism, immunity, and autophagy. They may be effective intervention targets in the prevention and treatment of PTSD comorbidity with AS. Herein, we comprehensively review metabolic factors, including glutamate and lipid alterations, in PTSD comorbidity with AS and discuss the possible implications in the pathophysiology of the diseases.

Keywords: AMPK/mTOR; PI3K/AKT; atherosclerosis-; immune; metabolism; post-traumatic stress disorder.

Publication types

Review

Grants and funding

This research was funded by the Department of Science and Technology in Sichuan Province (2020YFS0240), Sichuan University “0 to one”innovation research project (2022SCUH0024), and West China Nursing Discipline Development Special Fund Project, Sichuan University (HXHL20020).