Salviae miltiorrhiza against human lung cancer: A review of its mechanism (Review)

Qingwen An; Mengting Wu; Chuqi Yang; Yewen Feng; Xuefei Xu; Hang Su; Guangji Zhang

doi:10.3892/etm.2023.11838

Salviae miltiorrhiza against human lung cancer: A review of its mechanism (Review)

Exp Ther Med. 2023 Feb 13;25(3):139. doi: 10.3892/etm.2023.11838. eCollection 2023 Mar.

Authors

Qingwen An^{1

2}, Mengting Wu^{1

2}, Chuqi Yang^{1

2}, Yewen Feng^{1

2}, Xuefei Xu^{1

2}, Hang Su^{1

2}, Guangji Zhang^{1

2

3}

Affiliations

¹ School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China.
² Key Laboratory of Blood-Stasis-Toxin Syndrome of Zhejiang Province, Hangzhou, Zhejiang 310053, P.R. China.
³ Traditional Chinese Medicine 'Preventing Disease' Wisdom Health Project Research Center of Zhejiang, Hangzhou, Zhejiang 310053, P.R. China.

Abstract

Lung cancer is one of the commonest malignant tumors in the world today, causing millions of mortalities every year. New methods to treat lung cancer are urgently needed. Salviae miltiorrhiza Bunge is a common Chinese medicine, often used for promoting blood circulation. In the past 20 years, Salviae miltiorrhiza has made significant progress in the treatment of lung cancer and is considered to be one of the most promising methods to fight against the disease. A great amount of research has shown that the mechanism of Salviae miltiorrhiza against human lung cancer mainly includes inhibiting the proliferation of lung cancer cells, promoting lung cancer cell apoptosis, inducing cell autophagy, regulating immunity and resisting angiogenesis. Research has shown that Salviae miltiorrhiza has certain effects on the resistance to chemotherapy drugs. The present review discussed the status and prospects of Salviae miltiorrhiza against human lung cancer.

Keywords: Salviae miltiorrhiza; lung cancer; molecular mechanisms; review; traditional Chinese medicine.

Publication types

Review

Grants and funding

Funding: The present study was supported by the research and development plan of Zhejiang Province-research on innovative drugs of traditional Chinese medicine (grant no. 2019C03072) and Key research project of Zhejiang Provincial Science and Technology Plan of Traditional Chinese Medicine Study (grant no. 2019ZZ006).